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Pharma Care
USP monograph modernization: Chemical medicines assay by potentiometric titration

USP monograph modernization: Chemical medicines assay by potentiometric titration

USP and Metrohm jointly developed a potentiometric titration method for potassium bicarbonate and potassium carbonate assay. The new method uses autotitration combined with suitable equivalence point detection fulfilling all USP method validation requirements as per USP General Chapter . Many of the chemical medicine assay procedures are done by manual...
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Metrohm Moisture Plus: Multi-parameter analysis in seconds

Mira DS: Identify hazardous and illicit substances quickly and safely

Metrohm’s Moisture Plus near-infrared (NIR) spectroscopy changes the way you do moisture analysis. It combines Karl Fischer titration, the gold standard for moisture analysis, with other analyses for different chemical and physical parameters into a single NIR measurement. This approach increases speed and lowers overall measurement costs. Most companies see...
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Metrohm Moisture Plus: Multi-parameter analysis in seconds

Best before …

Metrohm’s Moisture Plus near-infrared (NIR) spectroscopy changes the way you do moisture analysis. It combines Karl Fischer titration, the gold standard for moisture analysis, with other analyses for different chemical and physical parameters into a single NIR measurement. This approach increases speed and lowers overall measurement costs. Most companies see...
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Need ion chromatographic analysis but you don’t want a new software? Metrohm IC operates with Empower, too!

Need ion chromatographic analysis but you don’t want a new software? Metrohm IC operates with Empower, too!

Software validations are long and tedious for everyone involved. Utilising a central software to control instrument and log data can save days of validation time, if not longer. For the pharmaceutical industry, LC and HPLC analysis is prevalent, making it logical to focus on a single software platform for instrument...
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Metrohm Moisture Plus: Multi-parameter analysis in seconds

Metrohm Moisture Plus: Multi-parameter analysis in seconds

Metrohm’s Moisture Plus near-infrared (NIR) spectroscopy changes the way you do moisture analysis. It combines Karl Fischer titration, the gold standard for moisture analysis, with other analyses for different chemical and physical parameters into a single NIR measurement. This approach increases speed and lowers overall measurement costs. Most companies see...
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Measuring the pH value of dairy products

Measuring the pH value of dairy products

This Metrohm Bulletin describes methods for measuring the pH value of dairy products. Particular attention has been paid to the handling, maintenance, and storage of the pH electrodes. The Analysis Milk, cream, yoghurt The calibrated pH electrode is immersed in a suitable quantity of the sample so that the diaphragm...
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Non-aqueous titrations, simplified

Non-aqueous titrations, simplified

Cleaning electrodes getting you down? Relax, the Solvotrode easyClean is here to help. Non-aqueous titrations have a habit of producing gluggy, gelatinous messes that take forever to clean from an electrode. For regular non-aqueous electrodes this means blocked membranes and low electrolyte flow, which in turn leads to slow responses,...
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Determination of ascorbic acid (vitamin C) and its compounds

Determination of ascorbic acid (vitamin C) and its compounds

In addition to its natural occurrence in fruit and vegetables, ascorbic acid (Vitamin C) is used as an antioxidant in foods and drinks. Ascorbic acid is furthermore also to be found in numerous drugs. Ascorbic acid and its salts and esters can be determined with titration or by using polarography,...
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Moisture in a lyophilized pharmaceutical by near-infrared spectroscopy

Moisture in lyophilized pharmaceuticals by near-infrared spectroscopy

Metrohm near-infrared spectrometer in diffuse reflection mode is ideal for determining the residual moisture in a lyophilized pharmaceutical product. Analysis of residual moisture in a lyophilised pharmaceutical product by near-infrared spectroscopy (NIRS). Quantification of residual moisture in lyophilised parenteral products is an important measurement in the pharmaceutical industry. Analyses are...
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The determination of water content in margarine by Karl Fischer 899 Coulometer

Determination of the water content in tablets by automated Karl Fischer titration

The water content of tablets determines the release of their active ingredients as well as their chemical, physical, microbial and shelf-life properties. Accordingly, the water content is of crucial importance and has to be accurately determined. This paper describes the straightforward determination of the water content using automated volumetric Karl...
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Chloride, sulfite, and sulfate in a surfactant solution

Chloride, sulfite, and sulfate in a surfactant solution using Anion Chromatography

Determine chloride, sulfite, and sulfate in a surfactant solution using anion chromatography with conductivity detection after chemical suppression. Did you know? Another term for a surfactant, «tenside», goes back to the Latin «tensio», which means tension and refers to the alteration in surface tension under the influence of surfactants. This...
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Qualification of droplet morphology in hair conditioner by Vis-NIR spectroscopy

Qualification of droplet morphology in hair conditioner by Vis-NIR spectroscopy

Hair conditioners are used to enrich the look and refine the feel of hair. These cosmetic products are composed of water and hydrophobic ingredients, thus forming an emulsion with a specified droplet size. The droplet size varies throughout different processing steps. This parameter is of great importance, since this affects...
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Water in penicillin-G-potassium

Water in penicillin-G-potassium

Pour ca. 30 mL methanol into the titration vessel, add 5 g salicylic acid and condition the mixture. Then add ca. 1 g sample and start the water determination. The inexpensive 870 KF Titrino plus is a KF titrator for volumetric water content determination. With it, water contents from a...
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Automatic conductometry in water samples with low electrical conductivity in accordance with USP

Automatic conductometry in water samples with low electrical conductivity in accordance with USP 645

The USP describes a three step analysis. The first step consists of measuring the conductivity and comparing it to a conductivity limit correlated to the measured temperature. If the limit is not met, the second step is carried out. Here, the sample is tempered to 25 ± 1 °C followed by a conductivity measurement. If...
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Ion chromatography – a universal technique with many applications in the pharmaceutical industry

Ion chromatography – a universal technique with many applications in the pharmaceutical industry

Testing in a regulated environment High standards have to be met by the pharmaceutical industry when it comes to drug quality and safety. These standards are documented in pharmacopoeias as officially recognised pharmaceutical rules, and published as legal tools of customer protection by authorities such as governments and medical societies....
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Applied thermometric titration: determination of iodine value (IV) in fats and oils

Applied thermometric titration: determination of iodine value (IV) in fats and oils

The determination is conducted by dissolving a weighed sample in a non-polar solvent such as cyclohexane, then adding glacial acetic acid. Metrohm Application Note AN-H-076 describes the procedure. The double bonds are reacted with an excess of a solution of iodine monochloride in glacial acetic acid («Wijs solution»). Mercuric ions...
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Purity of sulfanilamide

Scientists at Metrohm develop and research continuously new solutions and methods for all kinds of analyses. The goal is to provide the highest accuracy and reliability of the results. These solutions are then published as application notes, bulletins or white papers on our website - accessible to everyone. Here we...
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Attend our free webinars on IC and NIR

Inline Sample Preparation in IC Learn how inline sample preparation can help you to deal with matrix components that interfere with your ion chromatography analyses. In addition, inline sample preparation can make your analyses faster, more cost-effective, and more accurate. Metrohm presents a IC webinar hosted by G.I.T. Laboratory Journal...
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Metrohm acquires majority of DropSens

The Switzerland-based Metrohm AG is pleased to announce the acquisition of the majority of share in DropSens S.L. The acquisition comes after a longer period of successful cooperation between the two companies in the development of screen-printed electrodes and portable electrochemical instrumentation. With the acquisition of DropSens, Metrohm benefits from...
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CHOOSE THE INSTALLATION PACKAGE YOU NEED

Choose the installation package you need

Metrohm Installation Services ensure a proper installation and commissioning of your new instrument. This ensures that you can rely on the quality of your analytical results from day one. Metrohm Installation Services ensure a proper installation and commissioning of your new instrument in accordance with the supplier’s specifications by trained...
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